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| Type |
Poster Presentation |
| Area |
Analytical Chemistry |
| Room No. |
Grand Ballroom |
| Time |
10월 19일 (금요일) 11:00~12:30 |
| Code |
ANAL.P-357 |
| Subject |
Electrochemical biosensor for detection of uric acid using polydopamine@multi-walled carbon nanotubes. |
| Authors |
Chang Jun Lee, Won-Yong Jeon*, Young Bong Choi*, Hyug-Han Kim*
Department of Chemistry, Dankook University, Korea
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| Abstract |
The uric acid has known as the bio-marker for early detection of the gout. The electrochemical biosensing has been applied for quantitative analysis of uric acid. The Polydopamine (PDA) is the good candidate for hydrophilic functionalization of the multi-walled carbon nanotubes (MWCNTs). The PDA coated MWCNTs (PDA@MWCNT) were adsorbed onto the indium tin oxide (ITO) electrode with uricase enzyme. Polyacrylic acid(PAA) was additionally coated to block the interfering substances. The modified electrodes were used to quantitatively analyze the uric acid by measuring with Cyclic Voltammetry(CV). Measurement of ascorbic acid(AA), dopamine(DA), and glucose, which are interference substrates in the human body, was shown no interference effect. The calibration curve was drawn using the uric acid of various concentrations(0.1, 0.5, 1.0, 1.5, 2.5, 5.0mM) as the above prepared electrode, and it was found that R2 = 0.99 showed good linearity. Finally, this study can be used for early diagnosis in the health care fields. |
| E-mail |
chang5654@naver.com |
|
122nd General Meeting of the KCS