|
|
| Type |
Poster Presentation |
| Area |
Material Chemistry |
| Room No. |
Grand Ballroom |
| Time |
10월 18일 (목요일) 11:00~12:30 |
| Code |
MAT.P-374 |
| Subject |
High-Performance Iron Oxide-Based T2 MRI Nanoprobes in Ultra-High Magnetic Field |
| Authors |
Jeong Chan Park
Pohang University of Science and Technology, Korea |
| Abstract |
To date, it has not been believed that superparamagnetic iron oxide (SPIO) nanoparticles (NPs) can offer improved performance in ultra-high magnetic field (UHF) MRI, because of their magnetization being saturated at low magnetic field. In this work, we provide a paradigm of hierarchical surface-structured, superparamagnetic (His) DyxFe3-xO4 NPs as a novel class of previously unexplored materials for superior T2 MRI nanoprobes at UHF (9.4 T). We found that His-DyxFe3-xO4 NPs (x = 0.2) possess a higher transverse relaxivity than unmodified His-SPIO NPs and a significantly enhanced r2/r1 ratio (up to ~10.4 times higher) than those of reported Dy-based T2 MRI probes at 9.4 T. Furthermore, we demonstrate the effects of surface design of DyxFe3-xO4 NPs on their magnetic relaxivity and in vivo performance at UHF. The markedly enhanced r2/r1 is attributed to the enhanced spin decoherence arising from the magnetic field inhomogeneity, as well as a freezing effect owing to stronger dipolar coupling of superparamagnetic His-DyxFe3-xO4 NPs (x = 0.2). Detailed experiment methods and results would be presented at this meeting. |
| E-mail |
goodnews1979@gmail.com |
|
122nd General Meeting of the KCS