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| Type |
Poster Presentation |
| Area |
Medicinal Chemistry |
| Room No. |
Grand Ballroom |
| Time |
10월 18일 (목요일) 11:00~12:30 |
| Code |
MEDI.P-287 |
| Subject |
(-)-Epigallocatechin (EGC) shows methylglyoxal (MGO)-trapping activity and thereby inhibitory activity against advanced glycation end product (AGE) formation |
| Authors |
Eunryeol Shin, Youhoon Chong*
Department of Biotechnology, Konkuk University, Korea
|
| Abstract |
Maillard reaction is a multistep non-enzymatic process which includes the reaction of glucose with free amino groups of proteins leading to the formation of highly reactive advanced glycation end products (AGEs). AGE modification of proteins and thereby damages to cells and tissues have been confirmed to contribute to the pathophysiology of aging and long-term complications of various age-related diseases. The major reactive carbonyl compound that forms AGEs is methylglyoxal (MGO), and trapping and inactivating MGO have been recognized as the most viable approach to anti-AGEs therapy. In this study, we have shown strong MGO-scavenging activity of (-)-epigallocatechin (EGC). EGC was equipotent to previously identified MGO-scavengers such as (-)-epigallocatechin gallate (EGCG) and quercetin. Also, EGC inhibited protein glycation caused by MGO. |
| E-mail |
ershin94@hanmail.net |
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122nd General Meeting of the KCS