|
Type |
Poster Presentation |
Area |
Medicinal Chemistry |
Room No. |
Grand Ballroom |
Time |
10월 18일 (목요일) 11:00~12:30 |
Code |
MEDI.P-289 |
Subject |
Anti-oxidative compounds and tyrosinase inhibitory compounds from Fallopia japonica |
Authors |
Zhou Xinxin*, Gyusun Jeong1, Heesu Kwon1, Bong Ho Lee2,*, Byong Wook Choi1,* Department of Chemical & Biological Engineering , Hanbat National University, China 1Department of Chemical & Biological Engineering, Hanbat National University, Korea 2Division of Applied Chemistry & Biological Enginee, Hanbat National University, Korea |
Abstract |
In our continuing search for biologically active compounds from oriental medicinal plants, Fallopia japonica was examined. Here, we documented the progress on the purification, biological activities and structural determination of the purified compounds. From the 100% methanol extract of Fallopia japonica, solvent partition were prepared by using n-hexane (FJH), chloroform (FJC), butanol (FJB) and water (FJW). Among them, the extracts in FJB possessed strong anti-oxidative and anti-tyrosinase activities. The extracts in FJB of Fallopia japonica showed 89.9% DPPH radical scavenging activity, and 67.2% tyrosinase inhibitory activity at 100 ppm. Using a series of ODS (octadecylsilyl) open column chromatography, four compounds, 13-FJB-282, 13-FJB-283, 13-FJB-4832 and 13-FJB-52, were purified. The chemical structures of 13-FJB-282, 13-FJB-283, 13-FJB-4832 and 13-FJB-52 were determined by 1H and 13C NMR and comparison of HPLC chromatogram with reference compounds. 13-FJB-282 was turned out to be Piceid. Our results suggest that four compounds extracted from Fallopia japonica showed strong anti-oxidative and anti-tyrosinase activities. |
E-mail |
zxx0306@naver.com |
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