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| Type |
Poster Presentation |
| Area |
Medicinal Chemistry |
| Room No. |
Grand Ballroom |
| Time |
10월 18일 (목요일) 11:00~12:30 |
| Code |
MEDI.P-290 |
| Subject |
EGCG derivatives reduce the expression of both urokinase plasminogen activator and plasminogen activator inhibitor-1 to show anti-metastatic activity |
| Authors |
Sunhye Shin, Youhoon Chong*, Kim Yoonjeong
Department of Biotechnology, Konkuk University, Korea
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| Abstract |
Urokinase plasminogen activator (uPA) and its inhibitor plasminogen activator inhibitor‐1 (PAI‐1) are established independent biomarkers for high metastasis risk in breast cancer. In this study, we investigated the regulatory activity of EGCG and its derivatives on uPA and PAI‐1 expression and thereby their anti-metastatic potential. EGCG showed only marginal effects on the uPA system and on the metastatic behavior of breast cancer cells (MDA‐MB‐231). However, the EGCG derivatives showed potent inhibition of PAI‐1 and uPA expression. The Ras‐extracellular‐signal‐regulated kinase (ERK), p38 mitogen‐activated protein kinase (MAPK), and phosphatidylinositol‐3‐kinase (PI3K)/Akt/NF‐κB pathways, which regulate uPA and PAI‐1 expression, were also affected by EGCG derivatives. In line with these findings, substantial reduction in metastatic behavior of MDA‐MB‐231 cells, such as adhesion, invasion, and migration, was observed in the presence of EGCG derivatives. Taken together, we have shown that the EGCG derivatives could suppress the metastatic behavior of MDA‐MB‐231 cells through regulation of uPA and PAI‐1. |
| E-mail |
ggulggul-_-@nate.com |
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122nd General Meeting of the KCS