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| Type |
Poster Presentation |
| Area |
Medicinal Chemistry |
| Room No. |
Grand Ballroom |
| Time |
10월 18일 (목요일) 11:00~12:30 |
| Code |
MEDI.P-294 |
| Subject |
Asymmetric squaraines bearing N-substituted Fischer's base moieties as anticancer photosensitizers: Synthesis, characterization and biological evaluation |
| Authors |
Hyoung-jin Choi, JuEun Kim, Hyejin Jeong, So-young Ma1, Jong dae Lee*, Bee Kim
Department of Chemistry, Chosun University, Korea
1Center for Photovoltaic Materials, Korea University, Korea
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| Abstract |
Condensation of squaric acid with N-substituted Fischer base moieties containing electron-donating substituents gave only the semisquaraines. However, with salts possessing electronegative and electron-withdrawing groups, the squaraine dyes were isolated in good yields. The semisquaraines formed undergo condensation with other N-substituted Fischer base yielding the asymmetrical squaraine dyes. These results demonstrate the role of electronic factors and provide valuable information for the design of efficient squaraine-based sensitizers that can have potential applications in photodynamic therapy. |
| E-mail |
chlgudwls93@naver.com |
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122nd General Meeting of the KCS