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| Type |
Poster Presentation |
| Area |
Medicinal Chemistry |
| Room No. |
Grand Ballroom |
| Time |
10월 18일 (목요일) 11:00~12:30 |
| Code |
MEDI.P-295 |
| Subject |
Spiropyran bearing N-substituted Fischer’s base moieties as anticancer photosensitizers: Synthesis, characterization and biological evaluation |
| Authors |
Se-young Park, Bee Kim, JuEun Kim, Hyejin Jeong, So-young Ma1, Jong dae Lee*
Department of Chemistry, Chosun University, Korea
1Center for Photovoltaic Materials, Korea University, Korea
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| Abstract |
Reversibly controlled generation of singlet oxygen from photosensitizing spiropyran systems has the benefits of selective cell killing and controllable effect time, but is a challenging option for photodynamic therapies. We found that Fischer’s base-containing various spiropyran dyes have photoswitching properties for both fluorescence and singlet oxygen generation in aqueous solutions and cells, and demonstrated that spiropyrans dye featuring induced enhanced photosensitization and emission could be potentially applied in photodynamic therapy studies on tumor cells. |
| E-mail |
chlaslgh203@naver.com |
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122nd General Meeting of the KCS