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|
| Type |
Symposium |
| Area |
Exosome: from Concept to Clinic |
| Room No. |
Room 314 |
| Time |
FRI 15:20-: |
| Code |
LIFE3-3 |
| Subject |
Harnessing Intercellular Transfer of Exosomes to Improve Drug Delivery |
| Authors |
Ji Ho Park
Bio and Brain Engineering, KAIST, Korea |
| Abstract |
Over the past decade, widespread progress in nanotechnology has produced an impressive array of nanodevices with powerful therapeutic properties. Nonetheless, our capacity to precisely home these devices to regions of disease in vivo has remained very limited and, despite three decades of research, ligand-targeted nanomedicines have yet to provide a benefit to patients. A fundamental limitation of current approaches to nanomedicine delivery is that they lack capabilities of tissue penetration of therapeutic agents. In this talk, I will introduce our recent approaches to leveraging biological nanoparticles to improve drug delivery. We have developed a series of drug delivery nanosystems where extracellular vesicles in the tumor microenvironment were engineered in situ to improve tumor penetration of functional and therapeutic compounds and the therapeutic efficacy. |
| E-mail |
jihopark@kaist.ac.kr |
|
122nd General Meeting of the KCS