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| Type |
Poster Presentation |
| Area |
Medicinal Chemistry |
| Room No. |
Grand Ballroom |
| Time |
10월 18일 (목요일) 11:00~12:30 |
| Code |
MEDI.P-298 |
| Subject |
Loreclezole as a new class of potent insect growth regulators with mosquitocidal activity |
| Authors |
Yunkyoung Hwang, Hee Nam Lim1, Ill young Lee1,*, Chan-Mo Yu
Department of Chemistry, Sungkyunkwan University, Korea
1Eco-Friendly New Materials Research Center, Korea Research Institute of Chemical Technology, Korea
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| Abstract |
The mosquito is about 3500 species exist on the earth and they mediates diseases such as malaria, dengue fever, Zika virus, Japanese encephalitis, epidemic, chikungunya and this like. Recently, Insect growth regulators (IGRs) could become an effective target to control mosquitoes by having selectivity to insects and relatively low toxicity. Juvenile hormone(JH)-based IGRs including JH agonists (JHAs) and antagonists (JHANs) fatally affect the physiological regulations in insects and are effective for control the target insects.
In this study, we introduce the Lorecrezole as a novel JH-based insect growth regulator by the two-hybrid yeast β-galactosidase assay method in a yeast cell from chemical library. To investigate the relationship of lorecelzole analogues between chemical structure and JHA activity, we prepared Lorecrezole derivatives and obtained their activities in vivo test. To evaluate the mosquito larvicidal activities of loreclezole and its analogues with high JHA or JHAN activities, the mortality of 3rd instar larvae of Aedes albopictus treated with these compounds was determined. Among these compounds, K8363A and K9001C showed the highest mosquitocidal activity.
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| E-mail |
dbsruddl2003@nate.com |
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122nd General Meeting of the KCS