|
|
| Type |
Poster Presentation |
| Area |
Medicinal Chemistry |
| Room No. |
Grand Ballroom |
| Time |
10월 18일 (목요일) 11:00~12:30 |
| Code |
MEDI.P-300 |
| Subject |
Screening of Gram-positive specific antibacterial agents |
| Authors |
Jonghoon Shin, Yong Rok Lee1,*, Kwang-sun Kim*
Chemistry, Pusan National University, Korea
1Division of Chemical Engineering, Yeungnam University, Korea
|
| Abstract |
Antimicrobial resistance (AMR) pathogens suggested that the deaths attributable to AMR will exceed 10 million per annum by year 2050. There is unmet need to eradicate AMR bacteria is developing specific, high-efficiency, and non-toxic antibiotics. In this study, new chemicals were synthesized by a novel method. Synthesized chemicals were further evaluated antibacterial activity against S. aureus, E. coli, and P. aeruginosa. Of the total 63 chemicals, four chemicals (KS-16, -17, -19, -22) showed good antibacterial activity against Gram-positive bacteria in terms of zone of inhibition (>10 mm). Furthermore, the measurement of MIC values showed that four chemicals were comparable to commercial antibiotic, streptomycin against S. aureus. Therefore, four compounds could be used as a platform for making new antibiotics against anti-S. aureus. In the future, it is necessary to identify antibiotic mechanisms of these compounds. |
| E-mail |
sjh02827143@pusan.ac.kr |
|
122nd General Meeting of the KCS