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| Type |
Poster Presentation |
| Area |
Medicinal Chemistry |
| Room No. |
Grand Ballroom |
| Time |
10월 18일 (목요일) 11:00~12:30 |
| Code |
MEDI.P-301 |
| Subject |
Synthesis of EGCG-amide and its specific cytotoxicity against highly metastatic breast cancer (MDA-MB-231) cells |
| Authors |
Taegum Lee, Youhoon Chong*, Sunhye Shin
Department of Biotechnology, Konkuk University, Korea
|
| Abstract |
(-)-Epigallocatechin gallate (EGCG), a major green tea flavonoid, is well known for its cytotoxic activity against various cancer cell lines. In this study, a new EGCG derivative with an amide linkage at the C3 position was synthesized by using oxidation followed by reductive amination strategy of the globally protected epigallocatechin. The newly synthesized EGCG-amide was investigated for its anticancer activity against a panel of cancer cell lines to show strong cytotoxicity against the highly metastatic breast cancer cells (MDA-MB-231). Given the importance of metastasis in the cancer treatment, the mechanism for specific cytotoxicity of the EGCG-amide against the MDA-MB-231 cell lines is of particular interest. Synthesis, anticancer activity, and identification of the target proteins of EGCG-amide will be presented. |
| E-mail |
co4121@naver.com |
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122nd General Meeting of the KCS