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| Type |
Poster Presentation |
| Area |
Life Chemistry |
| Room No. |
Grand Ballroom |
| Time |
10월 19일 (금요일) 11:00~12:30 |
| Code |
LIFE.P-427 |
| Subject |
Sensitive Near-Infrared Fluorescence Probe for H2O2 Imaging |
| Authors |
Sun Hyeok Lee, Minsoo Choi1, Jusung Cheon1, Chul Soon Park2, Chang-Soo Lee3,*
Department of Bio Engineering, University of Science & Technology, Korea
1Pharmaceutical engineering, Soonchunhyang University, Korea
2Polymer Engineering, Chonnam National University, Korea
3Center for Bio Nano Research, Korea Research Institute of Bioscience and Biotechnology, Korea
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| Abstract |
Hydrogen peroxide (H2O2) is one of reactive oxygen species (ROS) which play a significant role in aging and the development of chronic diseases such as cancer, stroke, nerve disorder and other. Especially, H2O2 is toxic owing to oxidation of proteins, membrane lipids and DNA by the peroxide ion, so detecting H2O2 is greatly important for diagnosing various chronic diseases. Up to date, effective methods for imaging H2O2 are still lacking though a lot of approach has been reported to detect H2O2 in solution. Therefore, it is required to develop a near-infrared (NIR) fluorescent detection probe for H2O2. In this study, we designed and synthesized novel NIR probes, NIR hemicyanine skeleton (HXPI) moieties, to detect H2O2 in aqueous media. Fluorescence of the NIR probes was enhanced when oxidized from boron group to hydroxyl group by H2O2. |
| E-mail |
tnsgur02@kribb.re.kr |
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122nd General Meeting of the KCS