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| Type |
Symposium |
| Area |
Bioinorganic Chemistry (Metals in Biology) |
| Room No. |
Room 323 |
| Time |
THU 17:00-: |
| Code |
INOR1-4 |
| Subject |
Application of Advanced EPR Spectroscopy for Bio-inorganic Chemistry |
| Authors |
Sun Hee Kim
Western Seoul Center, Korea Basic Science Institute, Korea |
| Abstract |
EPR spectroscopy has been proven to play a significant role to characterize paramagnetic species. For example, metal ions in metalloenzymes are reactive centers for various fascinating catalytic reactions that nature has shown us. Thus, to investigate these metal ions and radical cofactors, which is paramagnetic, EPR spectroscopy has been fruitfully exploited. Our group utilizes advanced EPR spectroscopy, i.e. multi-frequency, multi-technique pulse EPR, (for the first time in Korea) to elucidate molecular mechanisms of bio-catalysts by placing an emphasis on revealing structures of intermediates of interesting biomolecules. In addition, advanced EPR spectroscopy provides accurate spin Hamiltonian values which can be used for explanation of the electronic structures of short-lived intermediates species via in-depth analysis, hence may deepen our knowledge for understanding working mechanisms of the interesting catalytic reactions.
In this talk, I will present case studies of application of advanced EPR spectroscopy, the recent results from our group. These include structural studies of ternary complex of metal, amyloid peptide and a chemical regulator and metal-oxo species as an intermediate of catalytic reactions.
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| E-mail |
shkim7@kbsi.re.kr |
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122nd General Meeting of the KCS