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| Type |
Oral Presentation |
| Area |
Oral Presentation of Young Material Chemists |
| Room No. |
Room 322 |
| Time |
THU 09:42-: |
| Code |
MAT.O-7 |
| Subject |
Time-Controlled Nanoscale Delivery System |
| Authors |
Jihyeon Park, SeoYeah Oh, Dongjun Kim1, Wonsik Lee, Geonho Kim, Jiwon Kim*
School of Integrated Technology, Yonsei University, Korea
1School of integrated technology, Yonsei University, Korea
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| Abstract |
Many reactions, especially in vivo, are time-dependent since reactants degrade or change over time. Therefore, delivering cargoes at desired time points and positions in nanoscale is necessary and injection at different time points is possible. However, it is difficult to spatio-temporally control the transmission of cargoes especially within short period time because they proceed with random walk motion. Thus, nanomotors – which the velocity can be controlled in nanoscale fluid systems – can be good candidate. Since controlling with two different external driving force on the same type of nanomotor is challenging to precisely control the velocity, herein, we designed two (or more) types of nanomotor which can travel at different speeds under the same applied stimuli. The nanomotors were composed of gold head – silver flexible filament – nickel tail encapsulated with N-isopropylacrylamide (NIPAm) based hydrogel. The difference in speed was controlled by adjusting the length of each compartment whereas the cargo releasing time was regulated by optimizing the thickness of encapsulating hydrogel. Our nanomotor based nanoscale delivery system can control the delivery time down to a few minutes, which can possibly increase the efficiency of multiple drugs or gene editing (where the cargoes easily degrade/denature) and also be used in molecular communications for transmitting information through (bio)materials. We believe the spatio-temporally controlled nanoscale delivery system will broaden the range of application areas of nanomaterials by enhancing the spatial and temporal accuracy in delivering cargoes in nanoscale. |
| E-mail |
jihyeon4180@naver.com |
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122nd General Meeting of the KCS