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| Type |
Poster Presentation |
| Area |
Medicinal Chemistry |
| Room No. |
Grand Ballroom |
| Time |
10월 18일 (목요일) 11:00~12:30 |
| Code |
MEDI.P-306 |
| Subject |
3,5-Disubstituted indole derivatives as Pim kinase inhibitors |
| Authors |
Yanghwan Yun, Victor Sukbong Hong, Jinho Lee*
Department of Chemistry, Keimyung University, Korea
|
| Abstract |
Pim kinases (Pim-1, Pim-2, and Pim-3) are involved in many cellular processes such as survival, growth, cell cycle, proliferation and cell's metabolism. Pim kinases are frequently overexpressed in multiple cancer including solid tumors, leukemia and lymphoma. Pim kinases are an attractive therapeutic target in the development of anti-cancer agents. A novel series of 3,5-disubstituted indole derivatives were synthesized as Pim kinases inhibitors. Synthesized compounds showed potent inhibitory activities against Pim kinases. The most potent compound exhibited IC50s of 0.003μM for Pim-1 and 0.007μM for Pim-3. |
| E-mail |
zznx17@naver.com |
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122nd General Meeting of the KCS