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| Type |
Poster Presentation |
| Area |
Life Chemistry |
| Room No. |
Grand Ballroom |
| Time |
10월 19일 (금요일) 11:00~12:30 |
| Code |
LIFE.P-441 |
| Subject |
Identification of potent and selective natural product inhibitors targeting receptor-type tyrosine-protein phosphatase epsilon (RPTPε) associated with breast cancer |
| Authors |
Do Hee Ahn, Se Jeong Kwon1, Hyo Jin Kang2, Sang Jeon Chung3,*
Pharmacy, Sungkyunkwan University, Korea
1pharmacy, Sungkyunkwan University, Korea
2Department of Chemistry, Dongguk University, Korea
3College of Pharmacy, SungKyunKwan University, Korea
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| Abstract |
Receptor-type tyrosine-protein phosphatase (RPTPε) is a classical receptor type PTP encoded by the PTPRE gene. RPTPε is associated with EGFR and ERK1/2 signaling pathway with a positive feedback regulatory loop. It suggests a positive role for RPTPε in cell growth and survival. In human breast cancer cell lines, RPTPε is up-regulated and activated. It indicates up-regulation of RPTPε may contribute to survival of human cancer cell lines.
In this study, we have screened phytochemical library consisting of 658-purified single compounds for identifying potent and selective inhibitors of RPTPε. After screening assay, several hit compounds were studied in detail about Ki value and inhibition type. Moreover, we have investigated the efficacy of the inhibitors in human breast cancer cell lines. This study will suggest a valid therapeutic approach for the treatment of cancers.
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| E-mail |
ehgml94@naver.com |
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122nd General Meeting of the KCS