|
|
| Type |
Poster Presentation |
| Area |
Medicinal Chemistry |
| Room No. |
Grand Ballroom |
| Time |
10월 18일 (목요일) 11:00~12:30 |
| Code |
MEDI.P-317 |
| Subject |
Enhancing dual gene delivery efficiency using tannic acid to form AAV complex |
| Authors |
Ginah Han, Yunha Kim, Jae-hyung Jang*
Chemical and Biomolecular Engineering, Yonsei University, Korea
|
| Abstract |
Adeno associated virus (AAV) is a promising method for gene therapy. However, the biggest drawback of AAV is that it can only carry certain sizes of DNA. To overcome this situation, many scientists cut DNA in several suitable sizes to fit in AAV. Nevertheless, it shows low number of gene expression because all the DNA need to be injected to the target cell to be functional. The tannic acid works as a bond to hold different viruses together, which forms AAV complex. The efficiency of dual gene delivery increases as AAV complex gains entry into a cell. By using this novel AAV complex method, it will effectively deliver genes to the target cell. |
| E-mail |
ginahhan@yonsei.ac.kr |
|
122nd General Meeting of the KCS