122nd General Meeting of the KCS

Type Symposium
Area Exosome: from Concept to Clinic
Room No. Room 314
Time FRI 16:00-:
Code LIFE3-5
Subject Clinical application of stem cell-derived EV-therapy
Authors Oh Young Bang
Neurology, Samsung Medical Center, Korea
Abstract Stem cell therapy is the promising therapeutic strategies for human diseases with no curable treatment option. Extracellular vesicles (EVs) are defined as a heterogeneous population of small vesicles with a diameter of 0.1 to 1 μm. Beside the role of EVs in the biomarker research field, it has been identified that EVs have their own therapeutic functions: EVs play a critical role in the exchange of information between cells. For examples, EVs secreted from mesenchymal stem cells (MSCs) alter the behavior of the target cells and promote restorative processes. Recently, there have been advances in terms of modification of stem cell-derived EVs to enhance their functions and the methods for isolation and production of EVs. However, there exist several hurdles in the application of EVs in humans, and only few clinical trials was conducted in clinical trials. In this talk, the recent advances of stem cell-derived EV-based therapies, including their potential benefits and underlying mechanisms, will be discussed together with the current limitations in the application in human.
E-mail neuroboy50@naver.com