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|
| Type |
Poster Presentation |
| Area |
Life Chemistry |
| Room No. |
Grand Ballroom |
| Time |
10월 19일 (금요일) 11:00~12:30 |
| Code |
LIFE.P-448 |
| Subject |
A novel BODIPY based Chemosensor for Pd (II) ions in live cells. |
| Authors |
Kyung Tae Hong, Nicholas Asiimwe, Jimin Lee, Dhiraj Murale, Jun-Seok Lee*
Molecular Recognition Research Center, Korea Institute of Science and Technology, Korea
|
| Abstract |
Palladium has been used in industries due to its specific physicochemical properties, henceforth released in a large amount of residue into the environment. The released Palladium has adverse impact on human health by disturbing various cellular processes by binding with thiol-containing amino acids, proteins, DNA and other macromolecules present inside the cells. Therefore, there is high demands to develop the fluorescent sensor for the palladium ions. In recent years, optical (both colourimetric and fluorometric) technique has emerged out to be the most effective and convenient technique, due to high sensitivity, selectivity, low detection limits and naked-eye detection. Herein, a novel 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene (BODIPY) based fluorescence ‘turn-off’ probe (PdBD-1) have been designed and synthesized for selective detection of palladium(II) (Pd2+) ions with a limit of detection (LOD) of 1.66 μM. The quenching of fluorescence intensity is due to the heavy atom electronic effects of palladium. Using our turn-off probe, we demonstrated Pd2+ ions sensing in the live cell imaging application. |
| E-mail |
H18006@kist.re.kr |
|
122nd General Meeting of the KCS