122nd General Meeting of the KCS

Type Symposium
Area Recent Advances of Nanobiosensor for Detection of Disease Biomarkers
Room No. Room 321
Time FRI 16:00-:
Code ANAL2-5
Subject Structural analysis of early polyoxometalate nanoclusters using ion mobility-mass spectrometry
Authors Jongcheol Seo
Department of Chemistry, Pohang University of Science and Technology, Korea
Abstract Advances in nanotechnology have led to the development of highly sensitive and functional nanoscale sensing materials suitable for the biomolecular detection. One of the potential candidates for such nanobiosensor materials is the polyoxometalate nanoclusters which can mediate the electrochemical potential and/or catalytic activity of specific biological process. To obtain the specific properties for biosensing applications, the three-dimensional structures and conformations of the polyoxometalate nanoclusters and their functional assemblies should be properly precisely tailored. The very first step for such structural/conformational control is to determine the structures of various polyoxometalate clusters and to understand the cluster formation mechanisms. In the present work, a new analytical approach using ion mobility-mass spectrometry was used for the structural analysis of early polyoxomolybdate clusters. Since ion mobility-mass spectrometry enables to measure the collision cross section of mass-selected individual cluster ions, the structural evolutions during the early cluster growth via pH-dependent condensation process could be monitored. The result indicates the structural transitions between 1D chain, 2D ring, and 3D compact cluster motifs as the cluster size increases. The addition of a single proton is observed to strongly influence the the adopted structure as a result of intramolecular hydrogen bonding. This is the first results which successfully analyzed the structural transitions during the polyoxomolybdate cluster growth, which clearly demonstrated that the ion mobility-mass spectrometry has great potential to analyze the structures of various nanoclusters and assemblies for further design and preparation of nanoparticle-based nanobiosensors.
E-mail jongcheol.seo@postech.ac.kr