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| Type |
Poster Presentation |
| Area |
Electrochemistry |
| Room No. |
Grand Ballroom |
| Time |
10월 19일 (금요일) 11:00~12:30 |
| Code |
ELEC.P-502 |
| Subject |
Electrochemical modification of diazonium for highly sensitive impedimetric DNA sensor |
| Authors |
Sujin Kang, Yang-Rae Kim1,*, Suseong Kim1
Kwangwoon University, Korea
1Department of Chemistry, Kwangwoon University, Korea
|
| Abstract |
Electrochemical DNA sensors offer simple and rapid tools for detection of DNA sequences or damaged genes associated with human diseases. The performance of electrochemical DNA sensors is critically dependent on the process of the DNA immobilization. In this study, 4-nitrobenzenediazonium was chosen as a diazonium compound and electrochemically modified on a gold electrode. Unlike thiol-based self-assembled monolayers, electrochemical reduction of diazonium is a more selective and desirable strategy in a view of resistance to electrochemical perturbation and long-term stability. Then nitro group was converted into amino group through electrochemical reduction processes. After glutaraldehyde treatment, probe DNA sequence for Dengue virus was finally immobilized for detection of target DNA. All processes were electrochemically monitored using cyclic voltammetry and electrochemical impedance spectroscopy of ferri/ferrocyanide. |
| E-mail |
rkdtnwls34@naver.com |
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122nd General Meeting of the KCS