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| Type |
Poster Presentation |
| Area |
Medicinal Chemistry |
| Room No. |
Grand Ballroom |
| Time |
10월 18일 (목요일) 11:00~12:30 |
| Code |
MEDI.P-323 |
| Subject |
Synthesis and biological effects of hydrogen sulfide donor peptide hybrids. |
| Authors |
Clovis Shyaka, Chung-Min Park1,*
Chemistry, Gangneung-Wonju National University, Korea
1Chemical Advanced Materials, Gangneung-Wonju National University, Korea
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| Abstract |
Hydrogen sulfide (H2S) has been known as a critical signaling molecule that regulates many physiological and/or pathological processes. With the multiple biological actions of H2S, there is growing interest in developing various H2S-releasing compounds for precise delivery of the gas to target tissues. Recently, the connection between drug and H2S-delivery components has led to a considerable variety of H2S donors with potential therapeutic effects against diseases. In our group, hydrogen sulfide (H2S)-releasing dithiolethione (ADT) functionalized with biologically active peptides are being investigated for their integrated anti-inflammatory and antioxidant potential. Herein, we report the synthesis of a series of H2S-releasing compound peptide hybrids and their initial biological effects. |
| E-mail |
parkc@gwnu.ac.kr |
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122nd General Meeting of the KCS