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|
| Type |
Poster Presentation |
| Area |
Life Chemistry |
| Room No. |
Grand Ballroom |
| Time |
10월 19일 (금요일) 11:00~12:30 |
| Code |
LIFE.P-456 |
| Subject |
New insights into the chemistry of biological systems studied by 17O NMR at 35.2 Tesla and molecular dynamics and quantum calculations |
| Authors |
Myunggi Yi
Department of Biomedical Engineering, Pukyong National University, Korea |
| Abstract |
Due to the broad linewidths of quadrupolar nuclei, in particular, 17O NMR application to biological systems has been limited. However, recent development in NMR spectroscopy at 1.5 GHz using a 35.2 tesla hybrid magnet improved 17O sensitivity and showed much narrower linewidths. To illustrate that new insights into the chemistry of biological systems can be observed with 17O spectroscopy, spectra of single site 17O labeled gramicidin A in liquid crystalline lipid bilayers have been recorded. While this monovalent cation selective channel has been characterized at high resolution by multiple technologies and labs, it has always been observed to be a symmetric dimer in the absence of ions until 35.2 T 17O spectroscopy showed that the symmetry is broken. Possible explanations due to water distribution in the channel pore studied by molecular dynamics simulations and quantum calculations will be discussed. |
| E-mail |
myunggi@pknu.ac.kr |
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122nd General Meeting of the KCS