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| Type |
Poster Presentation |
| Area |
Medicinal Chemistry |
| Room No. |
Grand Ballroom |
| Time |
10월 18일 (목요일) 11:00~12:30 |
| Code |
MEDI.P-326 |
| Subject |
Synthesis of A2B corroles for the application of photodynamic therapy |
| Authors |
Jihyeon Baek, Ung Jeong 1, Yonghwang Ha*
Department of Pharmaceutical Science, Jungwon University, Korea
1Department of pharmaceutical science, Jungwon University, Korea
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| Abstract |
Many researches are interested in developing tumor-specific destruction method. As an alternative therapeutic skill, photodynamic therapy (PDT) attracts great interests due to its high temporal and spacial selectivity to tumor cells. PDT is based on the photosensitizers which can generate singlet oxygen by energy transfer from triplet excited state sensitizers to molecular oxygen in ground state. Herein, we designed two types of free base A2B corroles and phosphorus corroles as photosensitizers, synthesized, and characterized the photophysical properties via measuring of UV-vis absorbance, and emission spectra, etc. For the next step, we are planning to synthesize various halogenated metallocorroles and investigating phosphorescence properties and application for tumor removal potential in cellular level. |
| E-mail |
hyh3455@jwu.ac.kr |
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122nd General Meeting of the KCS