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| Type |
Symposium |
| Area |
[KCS-Chemical Industry Joint Symposium] Thermo Fisher Technical Academia |
| Room No. |
Room 306A |
| Time |
FRI 10:30-: |
| Code |
KCS3-3 |
| Subject |
Orbitrap Technology |
| Authors |
Scott Peterman
Thermo Fisher Scientific, United States |
| Abstract |
The unique architecture of Orbitrap™ Tribrid™ mass spectrometers enables novel, powerful data acquisition methods to advance research. The combination of the quadrupole, Orbitrap, and dual pressure linear ion trap mass analyzers along with the ion routing multiple maximizes duty cycle, sensitivity, and selectivity to enable characterization and quantification of complex samples for both small and large molecule studies. In addition, detection in the Orbitrap enables ultra-high resolution and mass accuracy further differentiating instrument performance. Additional method and software features complete the workflow for automated data acquisition and processing.
The presentation will cover the new and unique acquisition methods for small molecule unknown identification and characterization as well as improved proteome coverage using bottom-up and top-down workflows. The presentation will highlight the AcquireX acquisition method as well as Compound Discoverer and Mass Frontier software used to acquire and process MSn data. For proteomics support, introduction of the FAIMS Pro interface to the Orbitrap Fusion Lumos Tribrid mass spectrometer has significantly increased the proteome coverage compared to data acquisition without FAIMS or TOF mass spectrometers. Proteomics support using the Tribrid mass spectrometer is also enhanced for top-down and in tact analysis.
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| E-mail |
Scott.peterman@thermofisher.com |
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122nd General Meeting of the KCS