123rd General Meeting of the KCS

Type Poster Presentation
Area Inorganic Chemistry
Room No. Exhibition Hall 2
Time 4월 18일 (목요일) 11:00~12:30
Code INOR.P-2
Subject Antimicrobial activity of robust porous Cu-MOFs containing glutarates and bipyridyl ligands
Authors Hyun-Chul Kim, Seong Huh, Sung-Jin Kim1, Youngmee Kim2,*, Do Nam Lee3
Department of Chemistry, Hankuk University of Foreign Studies, Korea
1Department of Chemistry and Nano Science, Ewha Womans University, Korea
2Institute of Nano-Bio Technology, Department of Chemistry and Nano Science, Korea
3Ingenium College of Liberal arts, Kwangwoon University, Korea
Abstract Four three-dimensional (3D) Cu-MOFs formulated as [Cu2(Glu)2(μ-L)]·x(H2O) (Glu is glutarate, and L is bpy = 4,4′-bipyridine (1), bpa = 1,2-bis(4-pyridyl)ethane (2), bpe = 1,2-bis(4-pyridyl)ethylene (3), and bpp = 1,2-bis(4-pyridyl)propane (4)) were synthesized by hydrothermal reactions or modified literature methods. Their crystal structures were slightly modified to increase their hydrolytic stabilities in aqueous solution. The antibacterial activities of the four Cu-MOFs, 1, 2, 3, and 4, were investigated by determining their MBC (minimal bactericidal concentration) values against five kinds of bacteria (Escherichia coli, Staphylococcus aureus, Klebsiella pneumonia, Pseudomonas aeruginosa, and Methicillin-resistant Staphylococcus aureus (MRSA)) which can cause water contamination, food poisoning, skin syndrome, purulent disease, pneumonia, and various diseases depending on the infection site. Although these Cu-MOFs are structurally very stable in aqueous medium during the antibacterial tests, they show excellent antibacterial activities against all five kinds of bacteria with very low MBCs. The robust porous 3D frameworks rather than the released CuII ions participate more strongly in inactivating bacteria.
E-mail mdkop@naver.com