123rd General Meeting of the KCS

Type Plenary Lecture
Area Plenary Lecture
Room No. Convention Hall 1+2
Time THU 13:30-14:20
Code PLEN-1
Subject High Resolution Ion Separations, Reaction, and Storage; Towards a Flexible Gas Phase Ion Chemistry Workbench based upon Structures for Lossless Ion Manipulations
Authors Richard D Smith
Biological Sciences Division, Pacific Northwest National Laboratory, United States
Abstract Gas phase ion chemistry is of broad interest and has importance in areas ranging from fundamental physics, to analytical chemistry, to biomedical research, and most of its applications are done in conjunction with the use of mass spectrometry (MS). New MS applications as well as related instrumental platform advances increasingly involve ion manipulations that are conducted between the ion source and MS analyzer. These manipulations include: ion transport through regions of elevated pressure, ion trapping, reactions (both ion-molecule and ion-ion), and ion mobility (IM)-based separations. While performing these manipulations can extend measurement capabilities or provide new kinds of information, the practicality of such manipulations becomes increasingly constrained by the cost and inefficiency of conventional instrumental designs and ion optic approaches as their complexity or the number of manipulation steps involved increases. For example, advances in MS-based analytical applications are often limited by their speed in conjunction with the use of liquid chromatography separations. In this regard, IM separations provide additional separation power and the basis for more sensitive, complete and effective analyses, as well as additional structure-related information (i.e., collision cross sections) that can be derived from these separations. The benefits of IM separations increase as separation power increases, and the limitations on both its resolving power and sensitivity have constrained applications of IM with MS.

To address these challenges, we are developing new approaches for ion manipulations based upon effectively lossless RF confinement achieved in readily fabricated Structures for Lossless Ion Manipulations (SLIM). An important aspect of these developments has been the use of traveling waves to drive and control ion motion in conjunction with SLIM. This has allowed the development of compact long separation path length (serpentine) designs that enable much higher resolution IM separations than previously feasible. The use of traveling waves in SLIM has also enabled a host of new capabilities. This includes the creation of extremely large ion trapping volumes and the ability in both spatially and temporally to compress ion populations, including IM separations, without loss of resolution.

This presentation will describe the basis for SLIM as well as recent developments that address many current challenges within a range of applications and that provide new capabilities, such as the basis for a broadly flexible ion chemistry workbench.
E-mail rds@pnnl.gov