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| Type |
Symposium |
| Area |
Recent Trends in Polymer Synthesis |
| Room No. |
Room 403 |
| Time |
FRI 09:25-09:50 |
| Code |
POLY2-2 |
| Subject |
Polymers and Polymerization for Coating Living Cells |
| Authors |
Sung Ho Yang
Department of Chemical Education, Korea National University of Education, Korea |
| Abstract |
Cytocompatible coating of living cells have drawn a great attention with aims of useful methods for protecting inner cells, providing chemical functionality on cell surfaces, and controlling cell proliferations. The first attempt of living cells coating has been conducted by organic polymers through layer-by-layer methods. The impact of works was under-evaluated in the biomedical fields because the method was limited to microbial cells and the macromolecular coating had no particular roles. To achieve more practical demonstration, coating materials shifted from organic polymers to inorganic materials, in other words, from soft to hard materials such as silica, titania, calcium carbonate, and calcium phosphate. The toughness of the inorganic materials were beneficial for protecting the cells and controlling cell division. In these works, the polymers have been used as catalytic templates for biomimetic synthesis of inorganic materials. On the other hand, it was developed a cytocompatible surface-initiated, atom transfer radical polymerization (SI-ATRP) method for grafting polymers from living cells with use of polydopamine priming. Considering a plethora of functional and structural variations in synthetic polymers, grafting polymers from (or to) cell surfaces would generate multifunctional cellular hybrids for many biotechnological and biomedical applications, not to mention providing an advanced tool for chemically manipulating the cells. |
| E-mail |
sunghoyang@knue.ac.kr |
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123rd General Meeting of the KCS