Despite their presence in small quantities in foods and plants, bioactive molecules provide great health benefits. However, because of high sensitivity to a number of factors such as light, temperature, and oxygen, it is important to stabilize these molecules and to find ways in preventing them from degradation to maximize their efficiency. Kojic acid as one of bioactive molecules, known to inhibit the formation of pigment in plant and animal tissues, is used on cut fruits to prevent oxidative browning, in seafood to preserve pink and red colors, and in cosmetics to lighten skin. It has also antibacterial and antifungal properties. In the present work, the layered yttrium hydroxide (LYH) was explored as a host material for the encapsulation of kojic acid to enhance its thermal and photo stabilities. The inclusion phenomena of kojic acid molecules into the interlayer gallery of LYH were compared with those into the interlayer of layered double hydroxide (LDH).