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| Type |
Poster Presentation |
| Area |
Organic Chemistry |
| Room No. |
Exhibition Hall 2 |
| Time |
4월 18일 (목요일) 11:00~12:30 |
| Code |
ORGN.P-153 |
| Subject |
Water soluble Nano Particles for Effective Drug Delivery in Photodynamic Therapy |
| Authors |
Yang Liu
Nano science and engineering, Inje University, Korea |
| Abstract |
Photodynamic therapy (PDT) is a treatment that uses a drug, called a photosensitizer or photosensitizing agent, and a particular type of light. When photosensitizers are exposed to a specific wavelength of light, they produce a form of oxygen that kills nearby cells. It has some advantages, such as:1)It has no long-term side effects when used properly.2)It’s less invasive than surgery.3)It usually takes only a short time and is most often done as an outpatient.4）It can be targeted very precisely.5）Unlike radiation, PDT can be repeated many times at the same site if needed.
Recently, our group developed a drug delivery system using gold nanorod (GNR) with anionic PS (sodium salt of purpurin-18) and cationic poly(allylamine hydrochloride) by layer-by-layer method, resulting in formation of GNR‒PS complex. This GNR‒PS complex is a promising agent for a synergistic (photothermal and photodynamic) therapy (PTT/PDT), in which PTT generates heat as well as operates the PS release which maximize the following PDT activity. The combined dual therapy, PTT followed by PDT, exhibits a significantly higher photocytotoxicity result based on synergistic effect of hyperthermia from PTT as well as singlet oxygen photogeneration from PDT. However, this system needs modification to deliver more amount of PS for enhancement of PDT result. More important thing is that the modified PS should be more soluble in water to get a balance for stability and reactivity.Our current work is focusing on improve the ps's water solubility by making them particle size.
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| E-mail |
gavin881027@gmail.com |
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123rd General Meeting of the KCS