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| Type |
Poster Presentation |
| Area |
Organic Chemistry |
| Room No. |
Exhibition Hall 2 |
| Time |
4월 18일 (목요일) 11:00~12:30 |
| Code |
ORGN.P-165 |
| Subject |
A fluorescent naphthalimide bearing thiosemicarbazide as a ratiometric fluorescent probe for the detection of nitric oxide |
| Authors |
Sujung Kim, Sun Young Park, Min Hee Lee*
Department of Chemistry, Sookmyung Women's University, Korea
|
| Abstract |
Nitric oxide (NO) is generated from L-arginine through nitric oxide synthase (NOS) catalyzed reaction in live cells. In particular, the NO plays a crucial role in diverse physiological and pathological processes, e.g., vasodilation, carcinogenesis, neurodegenerative disorders, neurotransmission, and etc. In this regard, we developed a ratiometric fluorescent probe 1 that can image NO in biological system. The probe 1 consists of naphthalimide as the signaling unit and thiosemicarbazide moiety as the recognition unit for NO. We think that the thiosemicarbazide moiety of probe 1 can react with NO selectively to form 1,3,4-oxadiazole heterocyclic product, leading to a ratiometric fluorescence change. |
| E-mail |
sujyungcc@naver.com |
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123rd General Meeting of the KCS