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| Type |
Poster Presentation |
| Area |
Organic Chemistry |
| Room No. |
Exhibition Hall 2 |
| Time |
4월 18일 (목요일) 11:00~12:30 |
| Code |
ORGN.P-167 |
| Subject |
A Series of Guanidine Conjugates with NSAID |
| Authors |
Ju Mi Lee, Jeong Tae Lee*
Department of Chemistry and Institute of Applied Chemistry, Hallym University, Korea, Hallym University, Korea
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| Abstract |
The guanidine derivative (9,13b-dihydro-1H-dibenzo[c,f]imidazo[1,5-a]azepin -3-amine hydrochloride) (1) is a fat cell stabilizer commonly used in eye inflammation caused by an allergic reaction. It is an optional H1 receptor antagonist which does not cross the blood brain barrier. Herein, a series of guanidine containing nonsteroidal anti-inflammatory drugs (NSAIDs) conjugates were synthesized based on coupling of different NSAIDs such as aspirin and salicylic acid with 1. Additionally, synthetic approach to other conjugates containing γ-aminobutyric acid (GABA) (neurotransmitter) and gabapentin (anticonvulsant agent) moieties as linkers as well as their biological evaluation are also in progress. |
| E-mail |
wnal0669@naver.com |
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123rd General Meeting of the KCS