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| Type |
Poster Presentation |
| Area |
Organic Chemistry |
| Room No. |
Exhibition Hall 2 |
| Time |
4월 18일 (목요일) 11:00~12:30 |
| Code |
ORGN.P-168 |
| Subject |
Syntheses and Biological Activities of Resveratrol Analogs with Nitrogen |
| Authors |
Lee Seul Park, Jeong Tae Lee*
Department of Chemistry and Institute of Applied Chemistry, Hallym University, Korea, Hallym University, Korea
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| Abstract |
Nitrogen-based heterocycles are important motifs in drug design and engineering of pharmaceuticals. A simple glance at FDA databases reveals that nearly 60% of unique small-molecule drugs containing a nitrogen heterocycle. Resveratrol (3,5,4'-trans-trihydroxystilbene) is a natural product known to exhibit strong antioxidant activity. To enhance its antioxidant efficacy, we have synthesized nitrogen-based heterocycles (quinoline, isoquinoline, quinoxaline, and quinazoline) containing resveratrol analogs using Wittig-Horner and metal-catalyzed reactions as key synthetic steps. Later, their antioxidant activity was measured by the ABTS assay and IC50 values of these compounds were also calculated. |
| E-mail |
hellobong3@nate.com |
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123rd General Meeting of the KCS