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| Type |
Poster Presentation |
| Area |
Medicinal Chemistry |
| Room No. |
Exhibition Hall 2 |
| Time |
4월 18일 (목요일) 11:00~12:30 |
| Code |
MEDI.P-376 |
| Subject |
1H-indole-3-acetic acid (IAA) derivatives for Butrylcholinesterase Inhibitor |
| Authors |
Minji Kim, Haneul Lee, Yujung Kang, Jintaek Oh, Minyeong Choi, Ji Hyun Hwang, Jeong Ho Park1,*
Department of Chemical & Biological Engineering, Hanbat National University, Korea
1Division of Applied Chemistry & Biological Enginee, Hanbat National University, Korea
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| Abstract |
We have been trying to find out new drug candidate compounds for Alzheimer's drugs based on the cholinergic theory. 1H-indole-3-acetic acid (IAA) is one of plant hormones and also shows anti-cancer effect. IAA derivatives were synthesized by the click reaction between propargylated IAA and substituted benzyl azide. In vitro cholinesterase [acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE)] inhibitory activities were evaluated by using IAA derivatives. Although the IC50 value of compound 6 is 15.15±0.87μM, it is a little bit less IC50 value than galantamine (IC50 = 9.4±2.5μM against BuChE). |
| E-mail |
alswla4553@naver.com |
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123rd General Meeting of the KCS