123rd General Meeting of the KCS

Type Poster Presentation
Area Medicinal Chemistry
Room No. Exhibition Hall 2
Time 4월 18일 (목요일) 11:00~12:30
Code MEDI.P-377
Subject Identification and Biological Activities of taxifolin in Wolfiporia extensa
Authors Sangwoo Kim, Minji Kim, Zhou Xinxin, Bong Ho Lee1,*
Department of Chemical & Biological Engineering, Hanbat National University, Korea
1Division of Applied Chemistry & Biological Enginee, Hanbat National University, Korea
Abstract In our continuing search for biologically active compounds from oriental medicinal plants, Wolfiporia extensa was examined and we have been able to identify taxifolin as an active compound. Here, we report the progress on the purification, identification, and biological activities of the compound. From the 100% methanol extract of Wolfiporia extensa, solvent partition were prepared by using n-hexane (WEH), chloroform (WEC), butanol (WEB) and water (WEW). Among them, WEB showed strong anti-oxidative and BuChE inhibitory activities. The extracts in WEB of Wolfiporia extensa showed 91.3% ABTS radical scavenging activity, and 41.2% BuChE inhibitory activity at 100 ppm. Taxifolin showed 30.1% BuChE inhibitory activity, 94.2% ABTS radical scavenging activity. Bioactive compounds were purified through a series of various chromatographic methods.
E-mail kimsw757@naver.com