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Type |
Poster Presentation |
Area |
Medicinal Chemistry |
Room No. |
Exhibition Hall 2 |
Time |
4월 18일 (목요일) 11:00~12:30 |
Code |
MEDI.P-377 |
Subject |
Identification and Biological Activities of taxifolin in Wolfiporia extensa |
Authors |
Sangwoo Kim, Minji Kim, Zhou Xinxin, Bong Ho Lee1,* Department of Chemical & Biological Engineering, Hanbat National University, Korea 1Division of Applied Chemistry & Biological Enginee, Hanbat National University, Korea |
Abstract |
In our continuing search for biologically active compounds from oriental medicinal plants, Wolfiporia extensa was examined and we have been able to identify taxifolin as an active compound. Here, we report the progress on the purification, identification, and biological activities of the compound. From the 100% methanol extract of Wolfiporia extensa, solvent partition were prepared by using n-hexane (WEH), chloroform (WEC), butanol (WEB) and water (WEW). Among them, WEB showed strong anti-oxidative and BuChE inhibitory activities. The extracts in WEB of Wolfiporia extensa showed 91.3% ABTS radical scavenging activity, and 41.2% BuChE inhibitory activity at 100 ppm. Taxifolin showed 30.1% BuChE inhibitory activity, 94.2% ABTS radical scavenging activity. Bioactive compounds were purified through a series of various chromatographic methods. |
E-mail |
kimsw757@naver.com |
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