123rd General Meeting of the KCS

Type Poster Presentation
Area Organic Chemistry
Room No. Exhibition Hall 2
Time 4월 18일 (목요일) 11:00~12:30
Code ORGN.P-181
Subject Synthesis and Activity Evaluation of Materials having excellent Liver cancer prevention and Anti-cancer activity
Authors Songmi Bae, Ju Hyun Song, Eon Jin Lee, Do hun Lee, Jong Hyun Cho1, Dai Il Jung*
Department of Chemistry, Dong-A University, Korea
1Department of Medicinal, Dong-A University, Korea
Abstract NAFLD is non-alcoholic fats, which is a type of fatty liver that occurs when fat builds up in the liver for reasons other than excessive alcohol use. Up to 80 percent of obese people have this disease. It is the most common liver disorder in developed countries. If found early on and treated, the results can be good, but it can develop into non-alcoholic steatohepatitis (NASH) for various reasons, leading to liver sclerosis and liver cancer. By Niche chemistry(esterification and acid condensation) we researched development of fresh and original medicines. Esters are formed from bioactive carboxylic acids and bioactive alcohols. Acid anhydrides can be obtained from condensation reaction known as a dehydration reaction. The substances we synthesized, ester and acid anhydride, are separated by a cation and anion with physiological activity, or separated by the original active substance, to represent their physiological activity, even before being passed to the blood when administered to the body. By applying this reaction process, we developed materials that have excellent liver cancer prevention and anti-cancer activity as well as new diet effects with low side effects and adverse reactions.
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