123rd General Meeting of the KCS

Type Symposium
Area Current Trends in Organic Chemistry Ⅰ: Synthetic Methodology and Application
Room No. Room 301+302
Time THU 16:10-16:35
Code ORGN1-2
Subject Synthetic Strategies for the Conjugated Polyene Chains of Carotenoids
Authors Sangho Koo
Department of Chemistry, Myongji University, Korea
Abstract Carotenoids are structurally interesting natural products containing the conjugated polyene chains of nine carbon-carbon double bonds, which exhibit antioxidant activity by scavenging reactive oxygen species (ROS). Certain carotenoids have vitamin A activity for cell growth and differentiation, and thus widely used as nutrition and drug. They are also utilized as coloring agents for foods and cosmetics due to their distinctive red colors. Various synthetic strategies for the conjugated polyene chains of the carotenoids will be discussed with special emphasis on the utilization of functionalized C5 and C10 units, designed for efficient construction of the carotenoids with nonpolar or polar terminal groups. C20 building blocks were devised for expeditious assembly of carotenoids, which allowed SAR of the terminal structures on the antioxidant activity of carotenoids by high throughput screening and hierarchical clustering analysis of ABTS and DPPH radical scavenging assays.
E-mail sangkoo@mju.ac.kr