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| Type |
Poster Presentation |
| Area |
Polymer Chemistry |
| Room No. |
Exhibition Hall 2 |
| Time |
4월 19일 (금요일) 11:00~12:30 |
| Code |
POLY.P-9 |
| Subject |
Mechanical properties of bio-printed vascular system |
| Authors |
Yeongheon Jung, Kwanwoo Shin*
Department of Chemistry, Sogang University, Korea
|
| Abstract |
Despite the significant advancements in bio printing and tissue engineering to mimic native tissue constructs, fabrication of bifurcating vessels and vascularized tissue constructs still pose a great challenge. Previous studies reported various fabricating method of artificial blood vessel which has limitations that control of vessel wall thickness, structural stability, free-standing printed model vasculatures with controlled lumen diameter and wall thickness.
The novel method to bioprint bifurcating vessels and develop hierarchical vasculature can overcome the downsides of previous studies. We designed a diffusive bioprinting method by incorporating calcium chloride in Pluronic F127 (PFCa) and casting of alginate/gelatin mixture over the extruded PFCa ink. The rheological properties of PFCa ink is defined. The wall thickness of artificial blood vessel depends on the pressure, nozzle size, incubation time are optimized. Artificial blood vessel, physically modified by acrylate and diacrylate, enables various possibilities of implantation and organ-on-a-chip.
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| E-mail |
stromatolightee@gmail.com |
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123rd General Meeting of the KCS