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| Type |
Poster Presentation |
| Area |
Organic Chemistry |
| Room No. |
Exhibition Hall 2 |
| Time |
4월 18일 (목요일) 11:00~12:30 |
| Code |
ORGN.P-182 |
| Subject |
Synthesized Curcumin Derivatives Target to β-amyloid Plaque by Optical Imaging of the Eye. |
| Authors |
Suah Yoo, Haebin Kim, Kyo-Chul Lee1,*, Dong Wook Kim2,*
Inha University, Korea
1Korea Institute of Radiological & Medical Science, Korea
2Department of Chemistry, Inha University, Korea
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| Abstract |
It has been demonstrated that the brain of Alzheimer’s disease (AD) patient is more stained by staining solutions than healthy brain because of an interaction between a staining solution and β-amyloid (Aβ) plaques. The deposition of β-amyloid (Aβ) plaques in the brain is the most significant target of molecular imaging due to a major pathological property of Alzheimer’s disease (AD). As flat structures of a compound fit into hydrophobic binding channels of Aβ plaques easily, the rigid conjugation planarity compounds have been used to detect the Aβ plaques. A visualization of cerebral Aβ plaques is considered to be the most feasible way to diagnose AD. However, almost common probes for AD showed relatively high nonspecific white matter uptake probably due to myelin uptake. This is an obstacle to demarcate the borders of the gray matter, where the Aβ plaques binding signals. Recently, it has been suggested that the Alzheimer’s peptide, Aβ, accumulates in the eye. In this study, PEGylated curcumin derivatives were synthesized for binding to Aβ plaques with high photoluminescence and enhanced blood circulation. Our synthesized PEGylated curcumin derivatives exhibit red region fluorescences which are appropriate biological Aβ plaques of optical imaging for AD diagnosis in the eye. |
| E-mail |
wn0232@naver.com |
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123rd General Meeting of the KCS