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| Type |
Poster Presentation |
| Area |
Organic Chemistry |
| Room No. |
Exhibition Hall 2 |
| Time |
4월 18일 (목요일) 11:00~12:30 |
| Code |
ORGN.P-185 |
| Subject |
Regioselective synthetic strategy of β-hydroxy sulfones |
| Authors |
Hyowon Park, Hye-Young Jang1,*
Department of Energy Systems Research, Ajou University, Korea
1Department of Chemistry, Ajou University, Korea
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| Abstract |
β-Hydroxy sulfones are synthesized by transition-metal catalyzed reactions, oxidant-mediated hydroxyl sulfonylation of alkenes, and ring opening reaction of epoxides with sulfinate salts. The previous reports show excellent yields, but they have environmental problems using toxic reagents and chemical issues related to regioselectivity issues. Moreover, commonly used sulfinate salts are relatively unstable and commercially limited. Therefore, it is important to develop an eco-friendly synthetic method for β-hydroxy sulfones in a regioselective manner. We investigated a regioselective β-hydroxy sulfones synthetic method using thiosulfonates as sulfonylating reagents, which are easily accessible by copper-catalyzed coupling of thiols. In this presentation, we will discuss detailed optimizations, substrate scopes, and the mechanism. |
| E-mail |
hyowon2010@ajou.ac.kr |
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123rd General Meeting of the KCS