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|
| Type |
Symposium |
| Area |
Recent Trends in Organometallic Chemistry |
| Room No. |
Room 401+402 |
| Time |
FRI 10:10-10:30 |
| Code |
INOR2-4 |
| Subject |
Transition-Metal-Catalyzed Decarboxylative Coupling Reactions |
| Authors |
Sunwoo Lee
Department of Chemistry, Chonnam National University, Korea |
| Abstract |
Transition-metal-catalyzed decarboxylative coupling of alkynoic acids have been studied by our lab for a decade. Since our first report that palladium-catalyzed reactions of aryl halides and propiolic acids afforded the symmetrical and unsymmetrical diaryl alkynes in good yields, a variety of related methodology have been reported by many research groups including us. The development of simple and convenient method for the preparation of aryl alkynoic acids made it easy accessible tool for the introduction of alkynyl group in organic synthesis. Although the decarboxylative coupling of alkynoic acids and Sonogahsira type coupling of terminal alkyne showed similar reactivity in most cases, the unique reactivity of alkynoic acid has been found. It is noteworthy that arylpropiolic acids readily prepared from the coupling reaction of aryl halides and propiolic acid without column chromatography procedure. In this presentation, we would like to discuss some of our recent research progress towards the decarboxylative coupling reactions of alkynoic acids. The synthesis of alkynyl ketone, propargyl amine, allyl nitrile and multi-halogenated compounds will be presented. |
| E-mail |
sunwoo@chonnam.ac.kr |
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123rd General Meeting of the KCS