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| Type |
Poster Presentation |
| Area |
Organic Chemistry |
| Room No. |
Exhibition Hall 2 |
| Time |
4월 18일 (목요일) 11:00~12:30 |
| Code |
ORGN.P-188 |
| Subject |
s-Triazine Based Oxidized Carbon Nitride : Directly 64Cu-Chelatable for PET Imaging |
| Authors |
Chul Hee Kim, Chan Ho Park, Kyo-Chul Lee1,*, Dong Wook Kim2,*
Inha University, Korea
1Korea Institute of Radiological & Medical Science, Korea
2Department of Chemistry, Inha University, Korea
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| Abstract |
Radio-labelled nanoparticles have been expected as one of the powerful imaging probe for diagnosing various diseases in modern positron emission tomography (PET). The conventional method to label radioactive metal ion to the nanoparticle is using chelators from its surface. However, functionalization of these chelators to nanoparticles was often strictly limited due to the properties of nanoparticles like absent of functional groups, sensitivity to harsh reaction conditions and low-functionalization yield. Here we suggest directly 64Cu-chelatable nanoparticle, oxidized carbon nitride (OCN). OCN was synthesized by top-down method via treating oxidant to s-triazine based carbon nitride and demonstrated its properties through many analytical instruments. OCN showed its high 64Cu-chelatable nature and targeting ability toward tumor by experiment on animals. |
| E-mail |
cg7633@naver.com |
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123rd General Meeting of the KCS