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| Type |
Poster Presentation |
| Area |
Life Chemistry |
| Room No. |
Exhibition Hall 2 |
| Time |
4월 19일 (금요일) 11:00~12:30 |
| Code |
LIFE.P-346 |
| Subject |
Co-formation of actins and microtubules; interaction and morphological aspects. |
| Authors |
ChangHo Kim, Sungwoo Jeong1, Kwanwoo Shin1,*
Institute of Biological Interfaces, Sogang University, Korea
1Department of Chemistry, Sogang University, Korea
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| Abstract |
The cytoskeleton in cell consists of three filamentous subsystems, microtubules, actin filaments and intermediate filaments. These have been studied for decades in cell, microtubule and actin in cytoskeleton play an important role in cell migration, division and cell shape changes. Microtubule and actin filament crosslink with coupling proteins or physically contact to perform an important role in cell functions. These coupling proteins for crosslink and mechanisms of actin-microtubule crosslinking have been studied and identified, but these studies were not performed in a highly controlled interface or a bulk. So, we developed to simulate a cytoskeleton formation through ATP-dependent actin polymerization and GTP-dependent microtubule polymerization in a bulk and a giant unilamellar vesicle. This research is restricted within the results in a bulk. For the results of a giant unilamellar vesicle, you can see on other poster of co-member. We represent actin polymerization, microtubule polymerization controlled with ion (Mg2+, Ca2+) concentration and actin-microtubule polymerization in a bulk. We will discuss the interaction and mechanism of actin-microtubule crosslinking in a bulk and in a highly confined as cell through a giant unilamellar vesicle on next time. |
| E-mail |
likejohn@hanmail.net |
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123rd General Meeting of the KCS