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| Type |
Poster Presentation |
| Area |
Medicinal Chemistry |
| Room No. |
Exhibition Hall 2 |
| Time |
4월 18일 (목요일) 11:00~12:30 |
| Code |
MEDI.P-380 |
| Subject |
Efficient and rapid synthesis of N-substituted isoquinolin-1(2H)-one under mild conditions: Facile access to doryamine derivatives |
| Authors |
Akshay Takwale, Yeong Uk Jeon1, Jong Yeon Hwang2,*
Medicinal chemistry and pharmacology, University of Science & Technology, India
1pharmacy, Sungkyunkwan University, Korea
2Center for Medicinal Chemistry, Korea Research Institute of Chemical Technology, Korea
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| Abstract |
We have depicted the simple and efficient synthesis of N-substituted isoquinolin-1(2H)-one derivatives. Initiating from coupling of benzoic acid containing vinyl ethers with different amines followed by rapid intramolecular cyclization under acidic conditions at room temperature. The utility of this simple and mild cyclization method has been demonstrated with the practical synthesis of natural product, doryamine and its analogues
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| E-mail |
dtakshay@krict.re.kr |
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123rd General Meeting of the KCS