123rd General Meeting of the KCS

Type Poster Presentation
Area Life Chemistry
Room No. Exhibition Hall 2
Time 4월 19일 (금요일) 11:00~12:30
Code LIFE.P-350
Subject Modulation of Cell Alignment Using Patterned Surface Charge without Topographical Depth Difference
Authors Dongkap Kim, Minsoo Kim1,*, Jaegeun Noh1,*, Youngdo Jeong*
Biomedical Research Institute, Korea Institute of Science and Technology, Korea
1Department of Chemistry, Hanyang University, Korea
Abstract Modulating the morphology of surface has been widely employed as a versatile tool for spatially controlling cell's growth, adhesion, and alignment based on the understanding of the interaction between cells and surface. Among many morphological modification, the strategy using various microgroove patterns has been widely applied. However, this strategy using various microgroove patterns is challenging to provide the environment for intercellular communications to maintain homeostasis due to the difference of depth between patterns. Herein, we report the alternative surface modification methods able to spatially control cell alignment and provide the environment for cell-cell communications as well, avoiding geometrical variations. The various patterns of the surface that consist of periodic areas with different charges were fabricated using photolithography and nanoparticle with charged ligands. The cells on the charged pattern without topographical depth difference showed aligned with orientation along the lines of the pattern. The surface can provide the more improved environment to communicate with gap junctions than the groove patterns surface. This strategy using the difference of charge density pave a new way to control the cell behavior on surfaces, providing the environment for intercellular communications.
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