123rd General Meeting of the KCS

Type Oral Presentation
Area Oral Presentation of Young Inorganic Chemists
Room No. Room 401+402
Time THU 09:20-09:30
Code INOR.O-3
Subject Chemical Strategies to Modify Amyloidogenic Peptides by Iridium(III) Complexes: Coordination and Photo-Induced Oxidation
Authors Juhye Kang, Jung Seung Nam, Tae-Hyuk Kwon1, Mi Hee Lim2,*
Department of Chemistry, Ulsan National Institute of Science and Technology, Korea
1Eco-Friendly Energy Engineering, Ulsan National Institute of Science and Technology, Korea
2Department of Chemistry, Korea Advanced Institute of Science and Technology, Korea
Abstract Amyloidogenic peptides are considered central pathological contributors towards neurodegeneration as observed in neurodegenerative disorders [e.g., amyloid-β (Aβ) peptides in Alzheimer’s disease (AD)]; however, their roles in the pathologies of the diseases have not been fully elucidated since they are a challenging target to be studied due to their heterogeneous nature and intrinsically disordered structure. Chemical approaches to modify amyloidogenic peptides would be valuable in advancing our molecular-level understanding of their involvement in neurodegeneration. In this presentation, effective chemical strategies for modifications of Aβ peptides implemented by a single Ir(III) complex in a photo-dependent manner will be presented and discussed. Such peptide variations can be achieved by our rationally designed Ir(III) complexes leading to the significant modulation of the aggregation pathways of Aβ40 and Aβ42, as well as the production of toxic Aβ species. Overall, we demonstrate chemical tactics for modifications of amyloidogenic peptides in an effective and manageable manner utilizing the coordination capacities and photophysical properties of transition metal complexes.
E-mail juhye@unist.ac.kr