123rd General Meeting of the KCS

Type Poster Presentation
Area Analytical Chemistry
Room No. Exhibition Hall 2
Time 4월 19일 (금요일) 11:00~12:30
Code ANAL.P-255
Subject One-pot Synthesis of Silicon Nanoparticles for Hyperpolarized 29Si Magnetic Resonance Imaging
Authors Quy Son Luu, Jiwon Kim, Jihye Jung, Youngbok Lee1,*
Department of Bionano Technology, Hanyang University, Korea
1Department of Bio-Nano Engineering, Department of , Korea
Abstract Silicon nanoparticles (Si NPs) has developed for application in medicine because of their biocompatibility, biodegradability, drug loading and imaging agents. Herein, we report a solution synthesis of Si NPs as hyperpolarized magnetic resonance imaging. The Si NPs was synthesized by the reduction of silicon tetrachloride using organic reductants at low temperature. This nanoparticles size and dispersity were controlled by investigation ratio of silicon precursor to reductant, temperature and various reducing agents. The chloride-terminated Si NPs was converted to hydroxy-terminated through methoxy-capped. And finally, hydroxyl group was altered by (3-aminopropyl)triethoxysilane (APTES) for enhancing the hydrophilicity and biocompatibility. The morphology, structure and physical properties of Si NPs were confirmed by transmission electron microscopy (TEM), X-ray diffraction (XRD), infrared spectroscopy (IR spectroscopy) and dynamic light scattering (DLS). This research recommends that controlling the size of silicon nanoparticles via colloidal synthesis as the contrast agents for hyperpolarized 29Si magnetic resonance imaging.
E-mail luusonquy@gmail.com