123rd General Meeting of the KCS

Type Poster Presentation
Area Medicinal Chemistry
Room No. Exhibition Hall 2
Time 4월 18일 (목요일) 11:00~12:30
Code MEDI.P-385
Subject Development of NIR imaging probes for diagnosis of Alzheimer’s disease
Authors Yihoon Kim, Sun-Joon Min*
Dept of Chemical & Molecular Eng/Applied Chemistry, Hanyang University, Korea
Abstract Alzheimer’s disease (AD) is a progressive neurodegenerative disease, which causes cognitive deficits that worsen over years. It may be the most costly diseases for society, which will probably increase with the ageing of society, becoming an important social problem. Clinical trial evidence shows that early recognition of cognitive impairment and clinical management at mild stages of AD delays the subsequent need for nursing home care. Consequently, it reduces the risk of misdiagnosis and inappropriate management. Aβ plaques and tau aggregates, characteristics of AD progression, have been used as biomarkers for diagnosis and monitoring of Alzheimer's disease. Fluorescence imaging is an ideal method to detect the Aβ plaques and tau aggregates due to its low cost, real time, and highly sensitive detection. Various chemical probes based on fluorescence dyes have been reported, but their low specificity to Aβ or tau proteins was not suitable for clinical application. Therefore, the development of new near-infrared fluorescence probes targeting these protein aggregates selectively are needed for diagnosis of Alzheimer's disease, in particular, early disease progression. In this report, we describe the synthesis of novel near-infrared fluorescence probes that selectively bind to Aβ and tau proteins. Based on our preliminary studies, we designed a series of compounds consisting of amino pyridine and dicyano indanes, which were synthesized by palladium-catalyzed coupling reactions and Knoevenagel condensations. Evaluation of the physicochemical properties of these probes and their biological efficacies against Aβ and tau proteins confirmed the possibility of their use as NIR fluorescent probes for diagnosis of Alzheimer’s diseases.
E-mail kyhoon0211@gmail.com