123rd General Meeting of the KCS

Type Poster Presentation
Area Life Chemistry
Room No. Exhibition Hall 2
Time 4월 19일 (금요일) 11:00~12:30
Code LIFE.P-355
Subject Self-degradable Graphene Nanomedicine Operated by DNAzyme for Cancer Therapy and Clearance
Authors Hyori Lee, Junseok Lee1, Won jong Kim*
Department of Chemistry, Pohang University of Science and Technology, Korea
1Pohang University of Science and Technology, Korea
Abstract It has drawn great interest in drug delivery to fabricate multifunctional nanocmedicine for cancer therapy. Graphene oxide (GO) have attracted much attention in biomedical applications due to mechanical and chemical stability, abundant oxygen functional groups on large surface area, and photothermal effect. However, recent studies have shown that GO accumulates in certain organs, which can cause potential toxicity. G-quadruplex (G4)/hemin-based DNAZymes have been known for their peroxidase activity mimicking the horseradish peroxidase (HRP). Herein, we designed GO-G4-hemin complex for enhanced anticancer therapy and clearance of nanomedicine. This conjugated duplex G4 sequence is employed for intercalation of anticancer drug between DNA base pair, enabling anticancer drug release and formation of G4/hemin complex upon irradiation with infrared light. The G4/hemin complex bound to GO induced the oxidation and degradation of GO in hydrogen peroxide-rich tumor microenvironment. The described nanomedicine provides a versatile platform for stimuli-responsive cancer therapy and clearance.
E-mail leehyol2@postech.ac.kr