123rd General Meeting of the KCS

Type Poster Presentation
Area Life Chemistry
Room No. Exhibition Hall 2
Time 4월 19일 (금요일) 11:00~12:30
Code LIFE.P-356
Subject pPBA@TiO2-doxorubicin nanoparticles for targeted chemo-sonodynamic therapy of cancer
Authors Seonil Kim, Sooseok Im1, Junseok Lee1, Won jong Kim*
Department of Chemistry, Pohang University of Science and Technology, Korea
1Pohang University of Science and Technology, Korea
Abstract Ultrasound can penetrate much deeper in biological tissue because it is non-radiative and has a low tissue attenuation coefficient. The ability of ultrasound to activate some sensitizer such as porphyrin, titanium dioxide nanoparticle has led researchers to consider sonodynamic therapy (SDT) as a possible alternative to photodynamic therapy. Herein, we designed a ROS stimuli-responsive self-assembled nanoparticle that can be activated by ultrasound to generate ROS. Doxorubicin(DOX), a kind of anticancer drug, loaded titanium dioxide nanoparticle(TNP) are wrapped by polymerized pheny boronic acid(pPBA). pPBA can interact with DOX by making phenyl boronic ester coupling, and this coupling is sensitive to ROS generated by TNP under ultrasound stimuli. Also, phenyl boronic acid can target cancer cell, containing many sialyated protein that interact well with PBA. This system has potential of tumor targeting drug delivery system that treat tumor by combination of SDT and chemotherapy.
E-mail smartsi08@postech.ac.kr